你数学好吗？

Are you good at mathematics?

Are you good at math?

Are you good in math?

Source: Tatoeba

Sentence Composition

=1 你 nǐ you (informal, as opposed to courteous 您 nín)
=1 你 nǐ you (Note: In Taiwan, 妳 is used to address females, but in mainland China, it is not commonly used. Instead, 你 is used to address both males and females.)
2 数学 shùxué mathematics
=3 好 hǎo
  1. good
  2. appropriate; proper
  3. all right!
  4. (before a verb) easy to
  5. (before a verb) good to
  6. (before an adjective for exclamatory effect) so
  7. (verb complement indicating completion)
  8. (of two people) close; on intimate terms
  9. (after a personal pronoun) hello
=3 好 hào to be fond of; to have a tendency to; to be prone to
=4 吗 má (coll.) what?
=4 吗 mǎ used in 嗎啡 mǎfēi
=4 吗 ma (question particle for "yes-no" questions)